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The developmental and evolutionary mechanisms behind the emergence of human-specific brain features remain largely unknown. However, the recent ability to compare our genome to that of our closest relative, the chimpanzee, provides new avenues to link genetic and phenotypic changes in the evolution of the human brain. We devised a ranking of regions in the human genome that show significant evolutionary acceleration. Here we report that the most dramatic of these ‘human accelerated regions’, HAR1, is part of a novel RNA gene (HAR1F) that is expressed specifically in Cajal–Retzius neurons in the developing human neocortex from 7 to 19 gestational weeks, a crucial period for cortical neuron specification and migration. HAR1F is co-expressed with reelin, a product of Cajal–Retzius neurons that is of fundamental importance in specifying the six-layer structure of the human cortex. HAR1 and the other human accelerated regions provide new candidates in the search for uniquely human biology.
Scientists say they have discovered a gene sequence which appears to play a central role in giving humans their unique brain capacity.
The area, called HAR1, has undergone accelerated evolutionary change in humans and is active during a critical stage in brain development.
The researchers compared genes from humans, chimpanzees and other animals to try to see which set man apart.
The Nature study was led by the University of California, Santa Cruz.
Something caused our brains to evolve to be much larger and have more functions than the brains of other mammals
Dr David Haussler
The researchers say they have yet to determine the precise function of the gene.
But they say the evidence suggests it may play a role in the development of the cerebral cortex – and may help explain the dramatic expansion of this part of the brain during human evolution.
They used a sophisticated computer analysis technique to compare genes from various species and pinpoint those which have undergone accelerated evolutionary changes in humans.
This highlighted the HAR1 region of the human genome.
Specialised nerve cells
The researchers examined this area more closely in the lab to pin down its structure, the tissues in which it is active, and to try to better understand its function.
They found HAR1 was part of two overlapping genes, of which one – HAR1F – was active in special nerve cells called Cajal-Retzius neurons.
These cells appear early in embryonic development and play a critical role in the formation of the layered structure of the human cerebral cortex.
Cajal-Retzius neurons release a protein called reelin that guides the growth of neurons and the formation of connections among them.
HAR1F was found to be active at the same time as the reelin gene.
Lead researcher Dr David Haussler said: “We don’t know what it does and we don’t know if it interacts with reelin.
“But the evidence is very suggestive that this gene is important in the development of the cerebral cortex and that’s exciting because the human cortex is three times as large as it was in our predecessors.
“Something caused our brains to evolve to be much larger and have more functions than the brains of other mammals.”
The analysis showed that HAR1 is essentially the same in all mammals except humans. There were just two differences between the versions found in chickens and chimps.
However, there were 18 differences between the chimp version and the one found in humans – which scientists say is an incredible amount of change to take place in a few million years.
The researchers believe the key gene does not control the production of specific proteins as most genes do, but instead plays a role in modifying the function of other genes.
Professor Chris Ponting, of the University of Oxford, said this suggested that the rapid evolution of the human brain might be due to subtle fine-tuning of genetic function.
His colleague, Dr Gerton Lunter, said: “What is really interesting is that this is a special type of gene.
“It seems likely that it changes the way the brain is wired in some way.”
From 5 minutes 21 seconds in the History Channel movie above, they also talk about the HAR1
Don’t Go To Hell
A young Korean artist taken to Hell
In 2009, a young Korean artist who was attending an all-night prayer meeting, was visited by Jesus Christ. She was taken to see Hell and told by Jesus to draw what she saw, so that the world would know.
Artist Speaking: “As I was praying all night long, I was able to love Jesus more than ever. One day, Jesus came and said in my Heart,“I will show you the deeper things of Heaven.”
I thought I was going to visit heaven, but instead, we visited Hell.
As I followed Jesus, I cried the whole time. I then began to hear moans, screams, and wailing sounds.
Most people have a misconception about Hell. They are deluded and think that if they “Only Believe in Jesus Christ,” they will end up in Heaven. Some even think that once they die, there is nothing afterwards.
People believe as they think, and therefore they live their lives as they please…
Jesus also showed me that as people watch violent secular movies, demons would actually torment the person’s soul without the person realizing it. As a person watches the scenes from TV, their soul is tormented and wounded. Watching secular TV does not help Christians develop a loving relationship with our bridegroom Jesus.
I saw that when people were smoking and drinking, that spirits of snakes filled the alcoholic drinks and the cigarette smoke.
As Jesus witnessed the sins committed by man, He cried. satan and his demons would tie the bodies of sinners so tight with iron chains to control them. Therefore sinners would go deeper and deeper in sin.
I am pleading with you not to commit sin. Do NOT live as you desire. In Hell, the senses are hundreds of times more vivid than what we feel on Earth. The pain is more severe.
Jesus showed me how people fall into Hell.
Jesus: I see countless people falling into the eternal deep sea of the fire of Hell every single day…Please tell the people what you have witnessed in Hell! You must tell them about Hell! Tell people how awful and gruesome Hell is! You must paint the scene of Hell as if you are within my heart. Draw the scenes with My aching heart!
They are falling into the Fire of Hell.
Draw it with My aching heart….
He felt such pity for people who were falling into Hell every single day!
As I was painting the scenes of Hell, satan attacked me severely. But I wanted to show the world about Hell and the heart of Jesus through these paintings.
I saw people being tormented on a cross.
I saw people who did not want to eat the bread of life…(God’s Word)
There were people who would not discuss the things of their lives with Jesus, but made their own decisions, and followed their own will.
There were people who drank and ate prohibited things.
Jesus: Please tell people who hurt each other’s hearts by their words that they must not hurt or wound their brothers/sisters in Christ. They must not say things without care or love.
This is how Murderers, rapists and child kidnappers will be tormented.
This woman tries desperately to escape.
The punishment for liars.
Those people who stole money will be penetrated by arrows and needles.
In Hell, I saw a woman and her son who had died. In Hell they no longer loved each other. Because of the unbearable pain, they would do anything to escape the torment, even by stepping on each other.
Insects in Hell.
These insects are for people who committed sins by their thoughts. They were filled with their own thoughts and knowledge. Covered by countless maggots, their entire body is wounded by large insects; going in and out of the whole body, mouth, ears and head.
Persecution of the gospel:
The picture shows how demons would influence people to persecute, harass and kill the messengers of the full and true gospel.
These people were filled with their own thoughts and knowledge.
These people were obstinate in their thinking. They thought, “why would Jesus work in my life? Who am I? I don’t think He loves me. I am very evil. I don’t think He would love someone like me.“
They were also people who violated God’s word and ignore God’s commandments. They will be placed in an area similar to a frying pan, which was burning with Hell fire.
Those people who do not attempt to align their thoughts with God’s will end up in Hell. We must fix our minds and thoughts on God.
This torment was for those Christians who did not share the gospel. They did not evangelize the good news to the lost. They ignored their calling.
This torment was for the people who had ignored God’s word and still continued to commit sin. They are the ones who performed evil in the eyes of the Lord.
For those who worshiped idols, those that had evil thoughts and were stubborn in their ways.
Grumblers and complainers also wound up in Hell. [1st Corinthians 10:10]
Grumblers and complainers in their heart.
There is a place in Hell for men who cheated on their spouses. For those who became gay or bisexual. They were penetrated by knives and spears.
For those who became sexually corrupt, their private parts were being pierced by demons.
A raging fire all around, with no place to escape.
Hell is endless, the torments are endless.
For those who would not repent.
You must kill any devil that is living inside of you.
When people repent, they cross over from death to life, and Jesus is waiting for them on the other side. They drop their heavy load of sin, and start on the narrow path to life, and off the road to hell.
When we repent and pray before God, angel armies come down and pierce the demons with their swords.
Jesus said, “Focus Me. You must focus only Me.“
Jesus forgives our sins when we repent.
Repent of your sins and believe in Jesus!
If you do, Heaven is waiting for you, instead of Hell.
A place where you could be joyful and have a happy life forever!
Don’t go to Hell!!!
Shoppers began lining up to purchase Apple Inc.’s AAPL -0.68% third-generation iPad on Friday, as the technology giant tries to widen its lead in the fast-growing tablet market.
Snapping Up New iPads
A man in a mask celebrated with Apple store’s staff after buying a new iPad in Tokyo Friday.
Interactive: Exploring the New iPad
Explore features and specifications
Photos: The Apple Evolution
Take a look back at Apple’s innovations over the years.
Crowds were expected at Apple retail stores from Australia to Switzerland to become one of the first to buy the new iPad. The new tablet computer, priced starting at $499 in the U.S., has a higher-resolution screen and faster networking capabilities than its predecessor, which has dominated the market to date.
Apple stores in 10 countries, including Japan, France and the U.S., were opening at 8 a.m. local time Friday—in some cases, hours before usual—to accommodate what were expected to be big crowds. Select retailers like Best BuyCo., BBY +5.35% RadioShack Corp.,RSH +2.11% and Wal-Mart Stores Inc.WMT +0.25% will be selling the device as well.
Sales got under way first in Australia, where a queue of about 200 people stretched around the block outside Apple’s flagship store in Sydney Friday morning to be first to buy the new device. Police and security kept shoppers in line as hoots rang out inside the store as customers bought the new iPad.
Albert Chu, a 56-year-old bus driver from Sydney, bought two—a 64GB version for his daughter and 16GB version for his own use. “I will use it to trade stocks back in Hong Kong,” said Mr. Chu.
In Tokyo, more than 450 people stood in a line that stretched two blocks when the doors of the Apple store in the upscale Ginza neighborhood opened by 8 a.m. Most had started to line up once the early-morning commuter trains started running, according to 19-year-old college student Ryo Watanabe, who was the first in line.
Mr. Watanabe had taken turns waiting in line for 37 hours with his 20-year-old friend, Kento Inoue. Already an owner of the iPhone 4, iPhone 4S and the iPad 2, for which he had been around 14th in line to buy at its launch, Mr. Watanabe was determined to be first this time.
“The fact that the display has gotten better is a big enough reason for me to get it,” he said.
In Hong Kong, the mood outside the recently opened Apple store in the city’s Central district was more muted. Apple employees were the rowdiest bunch, cheering and clapping as the customers were led inside.
Earlier in the week, dozens had queued for days near the Hong Kong Apple store, despite police efforts to disperse them. In a bid to discourage scalpers, Apple implemented an “iReserve” system that required customers to place reservations online. Demand overwhelmed the number of reservations available Thursday, and only those with email confirmations were allowed to purchase the device Friday.
The anticipation for the latest iPad has built steadily since it was announced last week by Apple Chief Executive Tim Cook at an event in San Francisco. The device is the first major product launch for Apple since the latest iPhone went on sale in October, and the company needs very strong sales for each new device it sells to meet Wall Street’s lofty expectations.
This time, Apple is trying to hold on to its roughly 60% share of the tablet market with a product that is considered a refinement of last year’s iPad 2, with a speedier graphics processor and voice dictation capabilities. Overall, Apple said it has sold more than 55 million iPads as of December.
But analysts said the lack of a dramatic design change in the new iPad could cause some customers to pass on purchasing–though other Apple products, such as the iPhone 4S, have thrived despite their physical similarities to previous generation products. If customers do decide to skip the newest iPad, Apple’s sales could still be buoyed by the existing iPad 2, which the company will continue to offer at a lower cost. The 16-gigabyte, wi-fi only model, for instance, will now cost $399.
The Cupertino, Calif., company said in recent days it had sold out of its allotment of iPad preorders, saying that interest among its customers was “off the charts.” The company has since said new preorders would take about two to three weeks to ship to customers.
Piper Jaffray forecasts Apple will sell more than a million new iPads on Friday, up from around 300,000 when the original iPad went on sale in April 2010. Several financial analysts are predicting sales of multiple millions over the first weekend.
Apple’s stock has climbed on the expectations and ensuing price upgrades. Apple shares have risen more than 40% since the start of the year and are approaching $600 a share.
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Given its market supremacy in tablets, Apple probably doesn’t have to wow consumers with a fresh overhaul. But expectations are sky-high just the same.
Apple will discover whether its latest changes will be enough to get consumers to line up at its stores when its new iPad goes on sale a week from Friday.
The iPad that Apple CEO Tim Cook introduced Wednesday is faster and offers a dramatically sharper display but otherwise looks quite similar to past iPads. And whether the new iPad will appeal strictly to folks who haven’t yet bought one is a key question facing the iconic company as it launches its first major new product since the 2011 death of co-founder Steve Jobs. Apple is increasingly dependent on “post-PC devices” — including the iPad, iPhone and iPod Touch — which accounted for 76% of its revenue last year.
In the almost two years since the original iPad was introduced, Apple’s tablet has been a dazzling success. It has sold more than 55 million units, and analysts expect it to top 100 million by year’s end. But Apple is facing ever-stiffer competition in the very market that it, more than any other company, has established. By Cook’s estimation, more than 100 competitive tablets were introduced in 2011.
While none have come close to matching the iPad’s success — the most successful, Amazon’s Kindle Fire, has sold in the “millions,” according to Amazon — several high-profile products have been introduced or are on the way. These include many of the Galaxy Tab models that Samsung has introduced.
Talking Tech: At the scene of Apple’s iPad unveiling in San Francisco.
Before the end of the year, Microsoft and its partners are expected to unleash new tablets based on the promising Windows 8 operating system. And more tablets will have the latest Android version, 4.0, or Ice Cream Sandwich. But Apple maintains a huge advantage in the more than 585,000 apps available in its App Store, including more than 200,000 native iPad apps.
The third-generation iPad — just plain “iPad” rather than the iPad 3 that some expected — adds several souped-up and highly anticipated features. Among them: a far crisper display, zippier processor, voice dictation and the ability to tap into the fastest 4G wireless data networks.
The new iPad is “taken to a whole new level and redefines the category Apple created with the original iPad,” Cook said at a press event here.
As with the previous iPad, the new iPad starts at $499 for a Wi-Fi-only model with 16 gigabytes of storage and jumps to $599 for a 32 GB version and $699 for 64 GB. Models that can provide speedy 4G data access when Wi-Fi isn’t available go for $629, $729 and $829, respectively. The new iPads will be available on March 16; Apple is taking preorders now.
iPad 2 price drops
Apple is keeping the prior-generation iPad 2 in the lineup, dropping the price to $399 for the 16 GB Wi-Fi version. That might make it somewhat more affordable to schools, an area of emphasis for Apple, which has been pushing digital textbooks lately. Also Wednesday, Apple unveiled a new version of its Apple TV set-top box, which brings Internet movies and TV shows — and music from your computer — to the TV set.
The latest box upgrades the high-definition video from 720p to a sharper 1080p and sells for the same $99. The Apple TV box will also be available on March 16. The company said nothing about rumors that it might ultimately bring out a full Apple-branded television set.
But most of the spotlight was focused on the brand-new iPad, and the early buzz has been positive.
“This is the best tablet on the market,” says Creative Strategies President Tim Bajarin, a leading tech analyst. Adds NPD analyst Ross Rubin, “It’s a significant improvement over the previous iPad.”
Arguably the killer feature on the latest model is the razor-sharp Retina display, a feature introduced on the iPhone 4 in 2010. “The Retina display is the thing that will set this apart and will make it hard for any of the competitors to match it,” Bajarin says.
This is the feature that Apple will be touting most loudly in its new iPad TV commercials, which they played for the press Wednesday. But Gartner analyst Michael Gartenbergsays, “Apple’s challenge is continuing to drive the message across. How do you show the display in a TV ad when it’s sharper on the iPad?”
Most high-definition TVs have a 1920×1080 resolution, but the sharper resolution of the iPad is 2048×1530, or “1 million more pixels than HDTV,” said Phil Schiller, Apple senior vice president. The result is that Web pages, text and videos will be especially crisp.
On the new models, Apple has maintained the 9.7-inch screen of earlier iPads, while claiming the same battery life of up to 10 hours (nine hours on 4G). (The battery is still sealed.) The overall design is only subtly different than predecessor models, with the new iPad slightly thicker. Most cases and accessories made by other companies ought to fit, but there are no guarantees.
While the outside looks nearly identical, the new, faster Apple-designed A5X chip with quad-core graphics doubles the processing speed of the A5 chip in the iPad 2. E-mails, videos, photos and other programs will open much faster.
There were expectations that Apple might add Siri, the loquacious digital personal assistant found in the iPhone 4S. That didn’t happen. But Apple did add voice dictation to the latest iPad. A new key with a microphone icon is on the keyboard. Press a button and you can dictate texts, e-mails and the like. Tap “done,” and the iPad converts your words into text. Apple says dictation works with third-party apps, so you can dictate your Facebook status or a caption in the Instagram photo app.
The improved camera in the new iPad mimics features introduced on the iPhone 4S — which many consumers have turned to in place of a point-and -shoot camera. The 5-megapixel camera has built-in image stabilization, to help eliminate the shakes, and offers the ability to shoot video in full 1080p HD resolution.
Some previous iPads could access cellular 3G networks; the new cellular-capable models can get faster 4G, available from AT&T and Verizon Wireless but not everywhere nationally. For now Verizon has a much larger footprint with the speediest of the 4G networks, those that access so-called LTE technology. Both Verizon Wireless and AT&T are keeping their data-pricing plans intact for the new iPad.
Verizon’s monthly tablet data plans begin at $20 for 1 GB, go to $30 for 2 GB and climb to $80 for 10 GB. AT&T offers a 250 MB plan for $14.99; 3 GB for $30; and 5 GB for $50.
Apple also introduced updates to several of its apps for the iPad, notably the iMovie video-editing app and GarageBand for playing music.
In iMovie, you can create movie trailers, as you can on Mac computers. New virtual instruments have been added to GarageBand.
Additionally, a touch-enhanced new version of iPhoto, the photo program on Mac computers, is now available for the iPad. With iPhoto — as opposed to the camera roll photo app on previous iPads — you can both edit photos and access the same libraries (“our vacation,” “baby born”) created on computers.
“The iPhone 4S proved that even when the tech press is expecting a more dramatic update, consumers feel differently,” says Forrester analyst Sarah Rotman Epps. “I don’t expect anything different from the new iPad. (It) may look similar to old models, but it’s a complete upgrade, with new battery, processor, software and screen. Consumers are going to love it.”
Apple shares rose 43 cents to close at $530.69 Wednesday.
The New iPad – Same price! From RM1,499
Start selling on 16 March 2012
Live in March 8, 2012 2am Malaysia Time (GMT+8)
Apple is expected to unveil its latest iPad today, though the rumor mill is also looking for word on lower-cost versions of earlier iPads and possibly an update on Apple TV. The Journal will live blog the Apple event here at 1 p.m. ET. The newest iPad is expected to have a sharper resolution screen, along with support for wireless carriers’ fourth generation LTE networks.
身边的时候你又抓不住！因为你不会抓！所以你还是一直是 打工仔！因为你的贫穷，所以你自卑！你退缩了！你什么都 不敢做！你只会给别人打工！所以你一直是打工仔！
师也不是一下子就能出口成章，骂人的时候很擅长，抱怨的 时候也很擅长，这也是口才，只是没有任何营养罢了，那是 没有价值的口才；看别人争论的时候，自己满嘴评头论足， 却不反省自己，倘若你做得好，你今天是否还说自己没口才
- 错！不是没有钱，而是没有赚钱的脑袋，工作几年了没有钱么，有了，但是花掉了，花在没有回报的事情上面，吃喝玩乐，或存放贬值了，没有实现最大化，所以钱就这样入不敷出，这样月光光 这样被生活所需全部一一使用，这样周而复始，每月做个月光族，没有远虑，当一天和尚敲一天钟，得过且过。
- 错！兴趣是什么，吃喝玩乐谁都有，没有成就哪里来的尽兴，出去旅游回来月光族，出去K歌 回头钱包空空，出去大量购物回来惨兮兮。打工有没有兴趣，挤公车有没有兴趣？上班签到下班打卡有没有兴趣？家里急需要一大笔钱的时候借钱有没有兴趣？要还钱没钱还有没有兴趣？卖老鼠药的人对老鼠药有没有兴趣……？
- 错！考虑做吧，有可能就成了！不做吧，好不甘心，整天上班也没有个头，还是做吧，明天开始，不过还是算了，再想想，这钱挣的也不容易，不不，就是打工挣钱也不容易，所以不能放弃机会，决定了，把握机会。 哎呀！天都黑了，明天再说吧！然后第二天又因为以上123456点，因为左思右想，继续循环，最终不能决定，犹犹豫豫，还是一无所获。